5-Chloro-2-hydroxybenzoic acid
5-Chlorosalicylic acid
CAS: 321-14-2
Molecular Formula: C7H5ClO3
5-Chloro-2-hydroxybenzoic acid - Names and Identifiers
| Name | 5-Chlorosalicylic acid |
| Synonyms | 5 CSA JACS-321-14-2 5-chloro-salicylicaci 5-Chlorosalicylic acid CHLOROSALICYLIC(5-) ACID 5-chloro-2-hydroxybenzoate 5-chloro-2-hydroxy-benzoicaci 2-Hydroxy-5-chlorobenzoic acid 5-Chloro-2-hydroxybenzoic acid 2-Hydroxy-5-Chloro Benzoic Acid 5-Chloro-2-hydroxybenzoic acid for synthesis |
| CAS | 321-14-2 |
| EINECS | 206-283-9 |
| InChI | InChI=1/C7H5ClO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,(H,10,11)/p-1 |
5-Chloro-2-hydroxybenzoic acid - Physico-chemical Properties
| Molecular Formula | C7H5ClO3 |
| Molar Mass | 172.57 |
| Density | 1.3766 (rough estimate) |
| Melting Point | 171-172°C(lit.) |
| Boling Point | 244.67°C (rough estimate) |
| Flash Point | 147.6°C |
| Water Solubility | 1 g/L (20 ºC) |
| Solubility | 1g/l |
| Vapor Presure | 0.000132mmHg at 25°C |
| Appearance | powder to crystal |
| Color | White to Almost white |
| BRN | 2046665 |
| pKa | pK1:2.63 (25°C) |
| PH | 2.5 (H2O, 20℃)(aqueous suspension) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.4580 (estimate) |
| MDL | MFCD00002457 |
| Physical and Chemical Properties | White crystalline powder. Melting Point 73-174 °c (172 °c, 174-176 °c). Soluble in hot water, insoluble in cold water, soluble in ethanol, ether, benzene, chloroform and acetic acid. With the role of ferric chloride was red-purple. |
| Use | Used as pesticide, medicine, dye intermediates |
5-Chloro-2-hydroxybenzoic acid - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R36/38 - Irritating to eyes and skin. R36/37/38 - Irritating to eyes, respiratory system and skin. R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. S37/39 - Wear suitable gloves and eye/face protection |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | VO2080000 |
| TSCA | Yes |
| HS Code | 29182990 |
| Hazard Class | 6.1 |
| Packing Group | III |
| Toxicity | LD50 oral in rat: 250mg/kg |
5-Chloro-2-hydroxybenzoic acid - Upstream Downstream Industry
| Raw Materials | Salicylic acid Chlorine |
5-Chloro-2-hydroxybenzoic acid - Introduction
White crystallinity. Soluble in hot water, hardly soluble in cold water, easily soluble in ethanol, ether, benzene, chloroform and acetic acid. It reacts with ferric chloride to be reddish purple. Water soluble 1g/L (20°C).
Last Update：2022-10-16 17:24:34
5-Chloro-2-hydroxybenzoic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
| uses | intermediates for dyes and medicines. Used as an intermediate for pesticides, medicines, and dyes |
| production method | add chlorobenzene to enamel pan and steam to remove water to below 0.03%, add salicylic acid, and uniformly pass chlorine to a predetermined amount at 110±2 ℃. Sampling and observing the precipitates cooled to 30 ℃, filtering, measuring the melting point, and taking 167-175 ℃ as the qualified, that is, the chlorobenzene solution of 5-chlorosalicylic acid is obtained. If the chlorination reaction is carried out under the irradiation of fluorescent lamp, the chlorine can be reached to the theoretical amount at 55-80 ℃. After the sampling test is qualified, the remaining chlorine is removed, cooled, filtered, washed with chlorobenzene, and dried to obtain the finished product. |
Last Update：2024-04-09 02:00:08
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Raw Materials for 5-Chloro-2-hydroxybenzoic acid